Chromatographic packing is a microsphere material with a nanoporous structure, which is used to separate and purify substances in chromatographic columns. It can be classified according to matrix and separation mode, with different characteristics and application scenarios. Chromatographic COFs resin is a new type of chromatographic medium based on covalent organic skeleton materials, which has high specific surface area and excellent stability. The specific separation of substances is realized by regulating the pore structure and surface functional groups. They have important application prospects in the fields of chemical analysis and biomedicine.